GETTING MY TRASTUZUMAB BIOSIMILAR TO WORK

The phosphorylated HER3 gives docking internet sites for p85 subunit of PI3K. The absolutely activated PI3K complicated is produced by binding of p110 subunit of PI3K to p85 which will be able to generate PIP3 by means of phosphorylating the PIP2. AKT binds to PIP3 and it is phosphorylated by PDK1 and mTORC2. Phosphorylation of AKT at both equally